Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 1/20 | 0.51 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.49 |
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.45 |
| ▸ | ABAT | P80404 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.45 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924648 | 0.78 | ERN1 (0.56) | ALDH1A1TSHRERN1AOX1FDPS | |
| SCHEMBL5991073 | 0.78 | CYP2A6 (0.47) | ALDH1A1ERN1PDGFRBPDGFRAMAOB | |
| SCHEMBL8503242 | 0.78 | MAOB (0.52) | ALDH1A1ERN1HPGDPDGFRBPDGFRA | |
| SCHEMBL3926144 | 0.78 | TTR (0.59) | ALDH1A1TSHRERN1AOX1FDPS | |
| SCHEMBL3920365 | 0.78 | ALDH1A1 (0.70) | ALDH1A1TSHRERN1AOX1FDPS | |
| SCHEMBL3920869 | 0.76 | ALDH1A1 (0.58) | ALDH1A1TSHRERN1AOX1FDPS | |
| SCHEMBL4446297 | 0.76 | TUBB4A (0.47) | ERN1PDGFRBPDGFRAMAOBMAOA | |
| SCHEMBL16711689 | 0.76 | ALDH1A1 (0.58) | ALDH1A1TSHRERN1AOX1FDPS | |
| SCHEMBL5842591 | 0.76 | IMPDH2 (0.48) | ALDH1A1TSHRERN1PDGFRBPDGFRA | |
| SCHEMBL3924578 | 0.75 | ALDH1A1 (0.56) | ALDH1A1TSHRERN1AOX1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |