Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6737941 | 0.89 | KCNH2 (0.52) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6737171 | 0.89 | KCNH2 (0.52) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6737490 | 0.82 | KCNH2 (0.41) | KCNH2MMP2MMP3KDM1AGRIN2B | |
| SCHEMBL6737648 | 0.81 | KCNH2 (0.40) | KCNH2MMP2MMP3KDM1AGRIN2B | |
| SCHEMBL6743533 | 0.81 | KCNH2 (0.40) | KCNH2MMP2MMP3KDM1AGRIN2B | |
| SCHEMBL6737925 | 0.81 | KCNH2 (0.40) | KCNH2MMP2MMP3KDM1AGRIN2B | |
| SCHEMBL6739839 | 0.81 | KCNH2 (0.40) | KCNH2MMP2MMP3KDM1AGRIN2B | |
| SCHEMBL6738637 | 0.81 | KCNH2 (0.40) | KCNH2MMP2MMP3KDM1AGRIN2B | |
| SCHEMBL6741109 | 0.81 | KCNH2 (0.51) | KCNH2MMP2MMP3KDM1AKDM4E | |
| SCHEMBL6733200 | 0.81 | KDM1A (0.37) | KCNH2MMP2MMP3KDM1AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229900-A1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229900-A1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ADRA1B, ADRB2, ADRA1D | KCNH2 13/4885MMP2 4073/4885MMP3 4101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.