Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.56 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744158 | 0.87 | KDR (0.43) | KDRFLT4FLT1NQO2ADORA2A | |
| SCHEMBL7739093 | 0.87 | KDR (0.66) | KDRFLT4FLT1ALOX15ADORA2A | |
| SCHEMBL7981125 | 0.82 | KDR (0.55) | KDRFLT4FLT1ALOX15ADORA3 | |
| SCHEMBL7981129 | 0.82 | KDR (0.55) | KDRFLT4FLT1ALOX15ADORA3 | |
| SCHEMBL7979692 | 0.77 | KDR (0.54) | KDRFLT4FLT1ALOX15ADORA3 | |
| SCHEMBL7744772 | 0.75 | KDR (0.61) | KDRFLT4FLT1ALOX15ADORA3 | |
| SCHEMBL7982719 | 0.75 | KDR (0.53) | KDRFLT4FLT1ALOX15ADORA3 | |
| SCHEMBL7982851 | 0.74 | KDR (0.52) | KDRFLT4FLT1ALOX15ADORA3 | |
| SCHEMBL7744191 | 0.74 | KDR (0.48) | KDRFLT4FLT1KMT2AMEN1 | |
| SCHEMBL7980284 | 0.73 | KDR (0.51) | KDRFLT4FLT1ADORA3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |
| US-6693134-B2 | ANTAGONIZING CHEMOKINE RECEPTORS BY ADMINISTERING 3-OXY-2-NAPHTHOIC ACID DERIVATIVES | CHEMOKINE THERAPEUTICS CORPORATION (CA) | 2004-02-17 | — | — | US | disclosed |
| US-20030045550-A1 | Bicyclic aromatic chemokine receptor ligands | CHEMOKINE THERAPEUTICS (CA) | 2003-03-06 | — | — | US | disclosed |
| WO-2002096397-A1 | BICYCLIC AROMATIC CHEMOKINE RECEPTOR LIGANDS | CHEMOKINE THERAPEUTICS CORPORATION (CA) | 2002-12-05 | — | — | WO | disclosed |
| EP-1097147-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-1097147-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-05-09 | — | — | EP | disclosed |
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | disclosed |
| WO-2000002871-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045550-A1 | Bicyclic aromatic chemokine receptor ligands | CXCL12, CCR5, CXCR1 | KDR 109/4885FLT4 118/4885FLT1 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.