SCHEMBL7980284

SCHEMBL7980284

COc1ccc(-c2cccc(-c3nc(-c4ccsc4)c(NC(C)=O)o3)c2O)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 6/20 0.51
FLT1 P17948 1/20 0.48
FLT4 P35916 1/20 0.48
HSP90AA1 P07900 5/20 0.42
MAPT P10636 5/20 0.40
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 2/20 0.40
LMNA P02545 1/20 0.40
GAA P10253 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
CCNE2 O96020 1/20 0.39
CDK4 P11802 1/20 0.39
CCND1 P24385 1/20 0.39
CCNE1 P24864 1/20 0.39
CDK2 P24941 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
GPR55 Q9Y2T6 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
HDAC4 P56524 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7982719 0.89 KDR (0.53) KDRFLT1FLT4MAPTGAA
SCHEMBL7980109 0.89 KDR (0.44) KDRFLT1FLT4HSP90AA1MAPT
SCHEMBL7982851 0.89 KDR (0.52) KDRFLT1FLT4MAPTALDH1A1
SCHEMBL7979692 0.87 KDR (0.54) KDRFLT1FLT4ADORA3HDAC4
SCHEMBL7981125 0.83 KDR (0.55) KDRFLT1FLT4MAPTALDH1A1
SCHEMBL7986016 0.79 KDR (0.46) KDRFLT1FLT4MAPTKDM4E
SCHEMBL7744772 0.78 KDR (0.61) KDRFLT1FLT4SMN1; SMN2ADORA3
SCHEMBL7986529 0.77 KDR (0.44) KDRFLT1FLT4HSP90AA1MAPT
SCHEMBL7981129 0.77 KDR (0.55) KDRFLT1FLT4MAPTALDH1A1
SCHEMBL7969458 0.77 KDR (0.46) KDRFLT1FLT4HSP90AA1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6228871-B1 THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY MERCK & CO., INC. 2001-05-08 US claimed