Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.54 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | UTRN | P46939 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982719 | 0.88 | KDR (0.53) | KDRFLT4FLT1NPC1RAB9A | |
| SCHEMBL7980284 | 0.87 | KDR (0.51) | KDRFLT4FLT1ADORA3HDAC4 | |
| SCHEMBL7982851 | 0.87 | KDR (0.52) | KDRFLT4FLT1ALOX15ADORA2A | |
| SCHEMBL7979899 | 0.86 | KDR (0.52) | KDRFLT4FLT1NPC1RAB9A | |
| SCHEMBL7981125 | 0.85 | KDR (0.55) | KDRFLT4FLT1ALOX15ADORA2A | |
| SCHEMBL7982616 | 0.84 | KDR (0.56) | KDRFLT4FLT1NPC1RAB9A | |
| SCHEMBL7981129 | 0.81 | KDR (0.55) | KDRFLT4FLT1ALOX15ADORA2A | |
| SCHEMBL7744772 | 0.80 | KDR (0.61) | KDRFLT4FLT1NPC1RAB9A | |
| SCHEMBL7986016 | 0.79 | KDR (0.46) | KDRFLT4FLT1NPC1RAB9A | |
| SCHEMBL7980109 | 0.79 | KDR (0.44) | KDRFLT4FLT1ADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |