Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | LAP3 | P28838 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6743353 | 1.00 | THRB (0.46) | THRBCYP3A4TAAR1ADRA2AADRA2C | |
| SCHEMBL20026233 | 0.79 | THRB (0.43) | THRBCYP3A4TAAR1CYP2D6SLC6A2 | |
| SCHEMBL12262583 | 0.78 | THRB (0.53) | THRBCYP3A4TAAR1ADRA2AADRA2C | |
| SCHEMBL18257694 | 0.78 | THRB (0.53) | THRBCYP3A4TAAR1ADRA2AADRA2C | |
| SCHEMBL16888402 | 0.78 | THRB (0.53) | THRBCYP3A4TAAR1ADRA2AADRA2C | |
| SCHEMBL3627338 | 0.78 | THRB (0.53) | THRBCYP3A4TAAR1ADRA2AADRA2C | |
| SCHEMBL10209766 | 0.76 | HTR2A (0.52) | THRBCYP3A4ADRA2ALMNAKDM4E | |
| Hydrochloric Acid SCHEMBL22774703 | 0.76 | ALDH1A1 (0.52) | THRBCYP3A4TAAR1ADRA2AADRA2C | |
| Hydrochloric Acid SCHEMBL22774850 | 0.76 | ALDH1A1 (0.52) | THRBCYP3A4TAAR1ADRA2AADRA2C | |
| SCHEMBL5872473 | 0.76 | TACR1 (0.47) | TAAR1ADRA2AADRA2CLMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689785-B2 | USEFUL PARTICULARLY AS REMEDIES FOR BONE DISEASES AND ARTHRITIS | NIPPON CHEMIPHAR CO., LTD. (JP) | 2004-02-10 | — | — | US | disclosed |
| EP-1342720-A2 | Epoxysuccinamide derivatives | NIPPON CHEMIPHAR CO., LTD. (JP) | 2003-09-10 | — | — | EP | disclosed |
| EP-1022276-B1 | EPOXYSUCCINAMIDE DERIVATIVES | NIPPON CHEMIPHAR CO (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-20020091131-A1 | Epoxysuccinamide derivatives | VELCURA THERAPEUTICS, INC. | 2002-07-11 | — | — | US | disclosed |
| US-6387908-B1 | BONE DISORDERS; ANTIARTHRITIC AGENTS | NIPPON CHEMIPHAR CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-1022276-A1 | EPOXYSUCCINAMIDE DERIVATIVES | NIPPON CHEMIPHAR CO., LTD. (JP) | 2000-07-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091131-A1 | Epoxysuccinamide derivatives | NR0B1, NR2E1, NR4A1 | THRB 1785/4885CYP3A4 375/4885TAAR1 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.