Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | AOC3 | Q16853 | 7/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | RGS12 | O14924 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9449194 | 1.00 | ADRA2C (0.61) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL9449308 | 0.82 | ADRA2C (0.59) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL13039135 | 0.79 | KDM4E (0.54) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL4272229 | 0.79 | KDM4E (0.59) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL28906870 | 0.79 | TAAR1 (0.45) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL5872473 | 0.79 | TACR1 (0.47) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL837417 | 0.79 | KDM4E (0.59) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL12418041 | 0.79 | KDM4E (0.59) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL9190252 | 0.79 | KDM4E (0.59) | ADRA2CKDM4EADRA2ALMNAHIF1A | |
| SCHEMBL5172179 | 0.79 | KDM4E (0.59) | ADRA2CKDM4EADRA2ALMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689785-B2 | USEFUL PARTICULARLY AS REMEDIES FOR BONE DISEASES AND ARTHRITIS | NIPPON CHEMIPHAR CO., LTD. (JP) | 2004-02-10 | — | — | US | disclosed |
| EP-1022276-B1 | EPOXYSUCCINAMIDE DERIVATIVES | NIPPON CHEMIPHAR CO (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-20020091131-A1 | Epoxysuccinamide derivatives | VELCURA THERAPEUTICS, INC. | 2002-07-11 | — | — | US | disclosed |
| US-6387908-B1 | BONE DISORDERS; ANTIARTHRITIC AGENTS | NIPPON CHEMIPHAR CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-1022276-A1 | EPOXYSUCCINAMIDE DERIVATIVES | NIPPON CHEMIPHAR CO., LTD. (JP) | 2000-07-26 | — | — | EP | disclosed |
| US-4644063-A | MUSCLE RELAXANTS; AGRICULTURE | NIPPON CHEMIPHAR CO., LTD. (JP) | 1987-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091131-A1 | Epoxysuccinamide derivatives | NR0B1, NR2E1, NR4A1 | ADRA2C 1361/4885KDM4E 703/4885ADRA2A 1527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.