Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742958 | 0.81 | CYP1A2 (0.62) | ALDH1A1GAAMAPTKMT2AMEN1 | |
| SCHEMBL7678368 | 0.80 | MAPT (0.51) | ALDH1A1GAAMAPTRAB9AKMT2A | |
| SCHEMBL4783318 | 0.80 | ALDH1A1 (0.46) | ALDH1A1MAPTRAB9ALMNAMAPK1 | |
| SCHEMBL11817806 | 0.75 | HDAC3 (0.41) | ALDH1A1GAAMAPTRAB9AKMT2A | |
| SCHEMBL8207668 | 0.74 | PDE4A (0.63) | ALDH1A1GAAMAPTRAB9AKMT2A | |
| SCHEMBL9418310 | 0.74 | RXFP1 (0.79) | ALDH1A1GAAMAPTRAB9AKMT2A | |
| SCHEMBL51509 | 0.74 | RXFP1 (0.79) | ALDH1A1GAAMAPTRAB9AKMT2A | |
| SCHEMBL28148908 | 0.74 | NPC1 (0.51) | ALDH1A1GAAMAPTRAB9AKMT2A | |
| SCHEMBL7430668 | 0.73 | NPSR1 (0.47) | ALDH1A1GAAMAPTRAB9AKMT2A | |
| SCHEMBL12362759 | 0.73 | TUBB4A (0.72) | ALDH1A1GAAMAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |