Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | FABP7 | O15540 | 1/20 | 0.50 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23175679 | 0.84 | SMYD3 (0.56) | SMYD3PTPN1NPC1 | |
| SCHEMBL3662896 | 0.79 | CRBN (0.52) | SMYD3MAOACRBN | |
| SCHEMBL7533313 | 0.79 | AHR (0.50) | SMYD3FABP7FABP5CRBN | |
| SCHEMBL21489762 | 0.78 | SMYD3 (1.00) | SMYD3 | |
| SCHEMBL19710217 | 0.78 | SMYD3 (1.00) | SMYD3 | |
| SCHEMBL23143564 | 0.74 | SMYD3 (0.68) | SMYD3PTPN1NPC1CRBN | |
| SCHEMBL10576398 | 0.74 | CMA1 (0.49) | SMYD3FABP7FABP5CRBN | |
| SCHEMBL395950 | 0.74 | TRPV1 (0.59) | PTPN1CASP3NPC1CRBN | |
| SCHEMBL396156 | 0.74 | DDX3X (0.59) | SMYD3ALDH1A1FABP7FABP5CRBN | |
| SCHEMBL6265770 | 0.72 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4EHSD17B10PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |