Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.49 |
| ▸ | AHR | P35869 | 4/20 | 0.46 |
| ▸ | CMA1 | P23946 | 2/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 4/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.43 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13529011 | 0.80 | CRBN (0.61) | CRBNAHRCMA1EIF2AK2TDP2 | |
| SCHEMBL13680598 | 0.78 | CRBN (0.50) | CRBNAHRCMA1EIF2AK2TDP2 | |
| SCHEMBL16321642 | 0.78 | ENPP3 (0.49) | CRBNAHRCMA1EIF2AK2GRIA1 | |
| SCHEMBL5873706 | 0.77 | TDP2 (0.70) | CRBNAHRCMA1EIF2AK2TDP2 | |
| SCHEMBL16321522 | 0.75 | CRBN (0.47) | CRBNAHRCMA1EIF2AK2GRIA1 | |
| SCHEMBL8265611 | 0.75 | CRBN (0.61) | CRBNAHRCMA1EIF2AK2TDP2 | |
| SCHEMBL278958 | 0.74 | AHR (0.61) | CRBNAHRCMA1EIF2AK2GRIA1 | |
| SCHEMBL16322576 | 0.74 | CMA1 (0.46) | CRBNAHRCMA1EIF2AK2TDP2 | |
| SCHEMBL6742551 | 0.72 | CRBN (0.50) | CRBNAHRCMA1EIF2AK2TDP2 | |
| SCHEMBL6359738 | 0.72 | CRBN (0.52) | CRBNAHRCMA1EIF2AK2TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689806-B1 | MODULATING PROTEIN KINASES AND RELATED SIGNAL TRANSDUCTION PATHWAYS | SUGEN, INC. | 2004-02-10 | — | — | US | disclosed |
| EP-1165513-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | Sugen, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056709-A1 | INDOLINONE COMPOUNDS AS KINASE INHIBITORS | SUGEN, INC. (US) | 2000-09-28 | — | — | WO | disclosed |