Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.58 |
| ▸ | PDE4A | P27815 | 6/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572501 | 0.89 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL29504585 | 0.89 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6745558 | 0.88 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6322653 | 0.82 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9167416 | 0.76 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1572976 | 0.75 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1572502 | 0.75 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9062953 | 0.75 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5708642 | 0.75 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7360467 | 0.75 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699903-B2 | HYDRATION OF THE ANHYDROUS LITHIUM SALT WITH ACETONITRILE AND WATER; PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2004-03-02 | — | — | US | disclosed |