Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 17/20 | 0.79 |
| ▸ | CA2 | P00918 | 17/20 | 0.79 |
| ▸ | CA9 | Q16790 | 17/20 | 0.79 |
| ▸ | CA12 | O43570 | 15/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | CA7 | P43166 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.60 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672980 | 0.88 | CA1 (1.00) | CA1CA2CA9CA12CYP1A2 | |
| SCHEMBL7759976 | 0.82 | MEN1 (0.68) | MAPTKMT2APOLBKDM4EMEN1 | |
| SCHEMBL672763 | 0.82 | CA12 (1.00) | CA1CA2CA9CA12CYP1A2 | |
| SCHEMBL7172778 | 0.81 | CA2 (0.56) | CA1CA2CA9CA12CYP1A2 | |
| SCHEMBL4554988 | 0.80 | KMT2A (0.69) | CA1CA2CA9CA12MAPT | |
| SCHEMBL13193500 | 0.80 | ALDH1A1 (0.69) | CYP1A2MAPTKMT2APOLBKDM4E | |
| SCHEMBL668108 | 0.80 | CA1 (1.00) | CA1CA2CA9CA12MAPT | |
| SCHEMBL671546 | 0.79 | CA2 (1.00) | CA1CA2CA9CA12CYP1A2 | |
| SCHEMBL7877742 | 0.79 | MEN1 (0.64) | MAPTKMT2APOLBKDM4EMEN1 | |
| SCHEMBL3406989 | 0.79 | CA2 (0.70) | CA1CA2CA9CA12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590938-A1 | NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH | Metasignal Therapeutics Inc. (CA) | 2013-05-15 | — | — | EP | claimed |
| WO-2012021963-A1 | NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH | METASIGNAL THERAPEUTICS INC. (CA) | 2012-02-23 | — | — | WO | claimed |
| EP-2590938-A1 | NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH | Metasignal Therapeutics Inc. (CA) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012021963-A1 | NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH | METASIGNAL THERAPEUTICS INC. (CA) | 2012-02-23 | — | — | WO | disclosed |