Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.88 |
| ▸ | TSHR | P16473 | 2/20 | 0.88 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL5344586 | 0.94 | ALDH1A1 (0.88) | ALDH1A1TSHRTDP1TP53MAOB | |
| Styrene SCHEMBL27635230 | 0.94 | ALDH1A1 (0.88) | ALDH1A1TSHRTDP1TP53MAOB | |
| Styrene SCHEMBL27670659 | 0.94 | ALDH1A1 (0.88) | ALDH1A1TSHRTDP1TP53MAOB | |
| Styrene SCHEMBL28366334 | 0.94 | ALDH1A1 (0.88) | ALDH1A1TSHRTDP1TP53MAOB | |
| Styrene SCHEMBL27689506 | 0.94 | ALDH1A1 (0.88) | ALDH1A1TSHRTDP1TP53MAOB | |
| Styrene SCHEMBL27689510 | 0.94 | ALDH1A1 (0.88) | ALDH1A1TSHRTDP1TP53MAOB | |
| Styrene SCHEMBL6258482 | 0.94 | ALDH1A1 (1.00) | ALDH1A1TSHRTDP1TP53MAOB | |
| Styrene SCHEMBL4986035 | 0.94 | ALDH1A1 (1.00) | ALDH1A1TSHRTDP1TP53MAOB | |
| Styrene SCHEMBL10892600 | 0.94 | ALDH1A1 (1.00) | ALDH1A1TSHRTDP1TP53MAOB | |
| Styrene SCHEMBL11144289 | 0.94 | ALDH1A1 (1.00) | ALDH1A1TSHRTDP1TP53MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693141-B2 | PHOTOCURABLE UNSATURATED MONOMER AND OPTIONALLY HEAT CURABLE MONOMER; PHOTOINITIATOR IS PREFERABLY A SILOXANE OLIGOMER CONTAINING A BENZOYL GROUP | CIBA SPECIALTY CHEMICALS CORPORATION | 2004-02-17 | — | — | US | disclosed |
| US-20020107297-A1 | Surface-active photoinitiators | IGM GROUP B.V. (NL) | 2002-08-08 | — | — | US | disclosed |
| US-6376568-B1 | MODIFIED POLYSILOXANE | CIBA SPECIALTY CHEMICALS CORPORATION | 2002-04-23 | — | — | US | disclosed |
| US-4281093-A | Catalyst compositions and their use in the preparation of release coatings | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-07-28 | — | — | US | disclosed |
| EP-0015346-A1 | Catalyst compositions and their use in the preparation of release coatings | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-09-17 | — | — | EP | disclosed |