Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.45 |
| ▸ | FEN1 | P39748 | 6/20 | 0.45 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6750087 | 0.89 | ALOX5AP (0.47) | LMNAARALOX5APFEN1 | |
| SCHEMBL6729590 | 0.87 | FEN1 (0.47) | LMNAARALOX5APFEN1PTGES2 | |
| SCHEMBL6747071 | 0.86 | FEN1 (0.44) | ALOX5APFEN1PTGES2MAOB | |
| SCHEMBL6750040 | 0.85 | PTGS2 (0.46) | ALOX5APFEN1PTGES2F10 | |
| SCHEMBL6837804 | 0.84 | CA1 (0.46) | LMNAARKCNA5KCNH2MAOB | |
| SCHEMBL6744800 | 0.84 | FEN1 (0.40) | ALOX5APFEN1PTGES2SCN9AAKR1C3 | |
| SCHEMBL6743644 | 0.84 | NPC1 (0.44) | ALOX5APFEN1SCN9A | |
| SCHEMBL6746036 | 0.84 | FEN1 (0.40) | ALOX5APFEN1PTGES2MAOB | |
| SCHEMBL6749848 | 0.84 | PTGES2 (0.44) | ALOX5APFEN1PTGES2KCNA5KCNH2 | |
| SCHEMBL6749461 | 0.82 | FEN1 (0.47) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |