Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.44 |
| ▸ | FEN1 | P39748 | 5/20 | 0.44 |
| ▸ | CA1 | P00915 | 5/20 | 0.42 |
| ▸ | CA2 | P00918 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6749867 | 0.87 | PTGS2 (0.49) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL6744782 | 0.87 | CA1 (0.39) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL6750040 | 0.85 | PTGS2 (0.46) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL6747322 | 0.85 | PTGS2 (0.50) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL6744800 | 0.85 | FEN1 (0.40) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL6742739 | 0.85 | PTGS2 (0.50) | ALOX5APFEN1PTGS2PTGS1 | |
| SCHEMBL6745215 | 0.85 | FEN1 (0.45) | ALOX5APFEN1PTGS2PTGS1 | |
| SCHEMBL6746699 | 0.84 | TGFBR1 (0.43) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL6749919 | 0.84 | PTGS2 (0.47) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL6746459 | 0.84 | CA1 (0.40) | ALOX5APFEN1CA1CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |