Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6750089 | 1.00 | SPHK1 (0.39) | SPHK1BRD4HSD11B2TACR1RORC | |
| SCHEMBL6186125 | 0.89 | CYP2D6 (0.42) | SPHK1BRD4HSD11B2ATM | |
| SCHEMBL6186128 | 0.89 | CYP2D6 (0.42) | SPHK1BRD4HSD11B2ATM | |
| SCHEMBL6748179 | 0.84 | SPHK1 (0.39) | SPHK1BRD4HSD11B2GPR119ATM | |
| SCHEMBL6748180 | 0.84 | SPHK1 (0.39) | SPHK1BRD4HSD11B2GPR119ATM | |
| SCHEMBL6750112 | 0.83 | SPHK1 (0.38) | SPHK1BRD4HSD11B2GPR119MEN1 | |
| SCHEMBL6191324 | 0.83 | SPHK1 (0.38) | SPHK1BRD4HSD11B2GPR119MEN1 | |
| SCHEMBL6751156 | 0.82 | SPHK1 (0.37) | SPHK1BRD4HSD11B2GPR119 | |
| SCHEMBL6748024 | 0.82 | GPR119 (0.39) | SPHK1BRD4GPR119 | |
| SCHEMBL6750858 | 0.82 | GPR119 (0.39) | SPHK1BRD4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242871-A1 | Novel arylheteroalkylamine derivatives | ASTRAZENECA AB (SE) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242871-A1 | Novel arylheteroalkylamine derivatives | CYP1A1, NOS3, NOS1 | SPHK1 1994/4885BRD4 3935/4885HSD11B2 894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.