Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8389663 | 0.90 | SMN1; SMN2 (0.36) | ERCC5FEN1SMN1; SMN2HPGDP2RX7 | |
| SCHEMBL8494921 | 0.88 | SMN1; SMN2 (0.35) | ERCC5FEN1SMN1; SMN2HPGDP2RX7 | |
| SCHEMBL7574482 | 0.84 | HPGD (0.33) | SMN1; SMN2HPGDP2RX7KMT2AALDH1A1 | |
| SCHEMBL8725793 | 0.83 | KMT2A (0.34) | SMN1; SMN2HPGDKMT2AHSD17B10 | |
| SCHEMBL8489056 | 0.82 | CYP2D6 (0.33) | SMN1; SMN2HPGDKMT2AALDH1A1 | |
| SCHEMBL8491762 | 0.82 | ERCC5 (0.45) | ERCC5FEN1P2RX7TAS1R3TAS1R1 | |
| SCHEMBL8388765 | 0.82 | PDE4D (0.36) | ERCC5FEN1SMN1; SMN2HPGDTAS1R3 | |
| SCHEMBL8813179 | 0.81 | SLC6A4 (0.45) | ERCC5FEN1P2RX7TAS1R3TAS1R1 | |
| SCHEMBL8490848 | 0.79 | NPC1 (0.36) | KMT2AALDH1A1 | |
| SCHEMBL8754724 | 0.78 | ALDH1A1 (0.32) | KMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696613-B2 | REACTING NITROHALOBENZENE DERIVATIVE WITH NITROETHANE IN PRESENCE OF A BASE SELECTED FROM THE GROUP CONSISTING OF A HYDROXIDE, A CARBONATE, A HYDRIDE, AN ALKOXIDE OF AN ALKALI OR ALKALINE EARTH METAL, AND GUANIDINE AND SOLVENT | RHONE POULENC AGROCHIMIE (FR) | 2004-02-24 | — | — | US | disclosed |
| US-20030097022-A1 | Process for preparing diketone compounds and precursors thereto | PEVERE VIRGINIE (FR) | 2003-05-22 | — | — | US | disclosed |
| US-6525225-B2 | Reacting a nitro-substituted acetophenone with (1) a mercaptan to replace the nitro group with an alkyl- or phenyl-thio group; or (2) nitroethane to replace the acetyl group with a 1-nitroethyl group | RHONE POULENC AGROCHIMIE (FR) | 2003-02-25 | — | — | US | disclosed |
| US-20020062045-A1 | Process for preparing diketone compounds and precursors thereto | PEVERE VIRGINIE (FR) | 2002-05-23 | — | — | US | disclosed |
| EP-0882028-B1 | NEW INTERMEDIATES TO PESTICIDES | AVENTIS CROPSCIENCE SA (FR) | 2002-01-16 | — | — | EP | disclosed |
| EP-0880498-B1 | PROCESS FOR PREPARING DIKETONE COMPOUNDS | AVENTIS CROPSCIENCE SA (FR) | 2001-11-21 | — | — | EP | disclosed |
| US-20010014761-A1 | Process for preparing diketone compounds and precursors thereto | PEVERE VIRGINIE (FR) | 2001-08-16 | — | — | US | disclosed |
| US-6235942-B1 | REACTION OF KETONE WITH CYCLOPROPANECARBOXYLIC ESTER TO FORM DIKETONE | RHONE-POULENC AGROCHIMIE (FR) | 2001-05-22 | — | — | US | disclosed |
| US-5859283-A | TERTIARY-BUTYL 3-CYCLOALKYL-3-OXOPROPIONATE | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1999-01-12 | — | — | US | disclosed |
| EP-0882028-A1 | NEW INTERMEDIATES TO PESTICIDES | Rhone Poulenc Agro (FR) | 1998-12-09 | — | — | EP | disclosed |
| EP-0880498-A2 | PROCESS FOR PREPARING DIKETONE COMPOUNDS | RHONE-POULENC AGROCHIMIE (FR) | 1998-12-02 | — | — | EP | disclosed |
| US-5747424-A | HEATING AN AROMATIC DIKETONE WITH A SALT OF HYDROXYLAMINE IN A SOLVENT | RHONE-POULENC AGRICULTURE LTD. (GB) | 1998-05-05 | — | — | US | disclosed |
| WO-1997030037-A1 | NEW INTERMEDIATES TO PESTICIDES | RHONE POULENC AGRO (FR) | 1997-08-21 | — | — | WO | disclosed |
| US-5656573-A | Herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-08-12 | — | — | US | disclosed |
| WO-1997028122-A2 | PROCESS FOR PREPARING DIKETONE COMPOUNDS | RHONE-POULENC AGROCHIMIE (FR) | 1997-08-07 | — | — | WO | disclosed |
| EP-0560482-B1 | 4-Benzoyl isoxazole derivatives and their use as herbicides | RHONE POULENC AGRICULTURE (GB) | 1997-08-06 | — | — | EP | disclosed |
| US-5650533-A | Intermediates to herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-07-22 | — | — | US | disclosed |
| EP-0560482-A1 | 4-Benzoyl isoxazoles derivatives and their use as herbicides | RHONE-POULENC AGRICULTURE LTD. (GB) | 1993-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010014761-A1 | Process for preparing diketone compounds and precursors thereto | KMO, DHCR7, KHK | ERCC5 2133/4885FEN1 4278/4885SMN1; SMN2 3618/4885 |
| US-20030097022-A1 | Process for preparing diketone compounds and precursors thereto | KMO, DHCR7, KHK | ERCC5 2133/4885FEN1 4278/4885SMN1; SMN2 3618/4885 |
| US-20020062045-A1 | Process for preparing diketone compounds and precursors thereto | KMO, DHCR7, KHK | ERCC5 2133/4885FEN1 4278/4885SMN1; SMN2 3618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.