Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 11/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 2/20 | 0.54 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30189508 | 1.00 | HTR1B (0.57) | HTR1BSLC6A4HRH1KCNA3HTR1D | |
| SCHEMBL4631786 | 0.85 | LMNA (0.54) | KDM4EALDH1A1HPGD | |
| SCHEMBL2177350 | 0.83 | HTR1B (0.78) | HTR1BSLC6A4HRH1KCNA3HTR1D | |
| SCHEMBL9770352 | 0.79 | KCNA3 (0.81) | HTR1BSLC6A4HRH1KCNA3HTR1D | |
| SCHEMBL8903484 | 0.78 | NQO2 (0.55) | KDM4EALDH1A1 | |
| SCHEMBL3267362 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1 | |
| SCHEMBL16902853 | 0.77 | KCNA3 (0.79) | HTR1BSLC6A4HRH1KCNA3HTR1D | |
| SCHEMBL16902840 | 0.77 | KCNA3 (0.79) | HTR1BSLC6A4HRH1KCNA3HTR1D | |
| SCHEMBL16902852 | 0.77 | KCNA3 (0.79) | HTR1BSLC6A4HRH1KCNA3HTR1D | |
| SCHEMBL16902854 | 0.77 | KCNA3 (0.79) | HTR1BSLC6A4HRH1KCNA3HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058263-A1 | COMPOUND LIBRARIES OF 2, 3, 4, 9-TETRAHYDROSPIRO (BETA-CARBOLINE-1, 4 -PIPERIDINE) DERIVATIVES AND RELATED COMPOUNDS FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO THE G-PROTEIN RECEPTOR | BIOFOCUS PLC (GB) | 2004-07-15 | — | — | WO | disclosed |