Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5720527 | 0.98 | TSHR (0.46) | TSHRPIK3CGPOLBNPC1RAB9A | |
| SCHEMBL14752446 | 0.80 | TSHR (0.50) | TSHRNPC1RAB9ASMN1; SMN2PARP1 | |
| SCHEMBL659214 | 0.79 | TSHR (0.71) | TSHRPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13035816 | 0.79 | TSHR (0.67) | TSHRPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL577244 | 0.75 | TSHR (0.47) | TSHRPIK3CGPOLBNPC1RAB9A | |
| SCHEMBL15006252 | 0.75 | TSHR (0.50) | TSHRPIK3CGPOLBNPC1RAB9A | |
| SCHEMBL12334407 | 0.75 | PIK3CG (0.56) | TSHRPIK3CGPOLBNPC1RAB9A | |
| SCHEMBL13870400 | 0.74 | ALDH1A1 (0.51) | PIK3CGPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL330155 | 0.74 | TSHR (0.46) | TSHRPIK3CGPOLBNPC1RAB9A | |
| Bromide SCHEMBL7295318 | 0.74 | TSHR (0.49) | TSHRPIK3CGPOLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239904-A | Chiral synthesis method of 2, 6-diamino-4, 5,6, 7-tetrahydrobenzothiazole optical isomer | 福建福瑞明德药业有限公司 | 2024-06-25 | — | — | CN | claimed |
| US-6770761-B2 | BROMINATION OF 1,4-CYCLOHEXANEDIONE BY BROMINE IN AN ALCOHOLIC SOLVENT; TREATMENT WITH THIOUREA OR N-ACYLTHIOUREA; ISOMERIZATION, CYCLIZATION; PRAMIPEXOLE SYNTHESIS | SYNTHON BV (NL) | 2004-08-03 | — | — | US | claimed |
| US-20040029936-A1 | Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles | SYNTHON IP INC. | 2004-02-12 | — | — | US | claimed |
| EP-1318986-A1 | PROCESS FOR PREPARATION OF 2-AMINO-6-(ALKYL) AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLES | Synthon B.V. (NL) | 2003-06-18 | — | — | EP | claimed |
| WO-2002022590-A1 | PROCESS FOR PREPARATION OF 2-AMINO-6-(ALKYL) AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLES | SYNTHON B.V. (NL) | 2002-03-21 | — | — | WO | claimed |
| CN-118239904-B | Chiral synthesis method of 2, 6-diamino-4, 5,6, 7-tetrahydrobenzothiazole optical isomer | 福建福瑞明德药业有限公司 | 2025-10-17 | — | — | CN | disclosed |
| CN-118239904-A | Chiral synthesis method of 2, 6-diamino-4, 5,6, 7-tetrahydrobenzothiazole optical isomer | 福建福瑞明德药业有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-118239904-A | Chiral synthesis method of 2, 6-diamino-4, 5,6, 7-tetrahydrobenzothiazole optical isomer | 福建福瑞明德药业有限公司 | 2024-06-25 | — | — | CN | disclosed |
| US-6770761-B2 | BROMINATION OF 1,4-CYCLOHEXANEDIONE BY BROMINE IN AN ALCOHOLIC SOLVENT; TREATMENT WITH THIOUREA OR N-ACYLTHIOUREA; ISOMERIZATION, CYCLIZATION; PRAMIPEXOLE SYNTHESIS | SYNTHON BV (NL) | 2004-08-03 | — | — | US | disclosed |
| US-20040029936-A1 | Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles | SYNTHON IP INC. | 2004-02-12 | — | — | US | disclosed |
| EP-1318986-A1 | PROCESS FOR PREPARATION OF 2-AMINO-6-(ALKYL) AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLES | Synthon B.V. (NL) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002022590-A1 | PROCESS FOR PREPARATION OF 2-AMINO-6-(ALKYL) AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLES | SYNTHON B.V. (NL) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029936-A1 | Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles | PAH, HTR6, HTR4 | TSHR 1593/4885PIK3CG 3177/4885POLB 1476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.