SCHEMBL6749378

SCHEMBL6749378

CO[Si](OC)(OC)c1ccc(N(c2ccc(C)cc2)c2ccc(C)cc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
ACHE P22303 2/20 0.34
TDP1 Q9NUW8 1/20 0.33
MAPT P10636 1/20 0.31
MCOLN3 Q8TDD5 1/20 0.31
CYP2C19 P33261 1/20 0.31
EGFR P00533 1/20 0.30
CSF1R P07333 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6748533 1.00 ALDH1A1 (0.39) ALDH1A1TSHRACHETDP1MAPT
SCHEMBL6748558 0.94 ALDH1A1 (0.35) ALDH1A1TSHRACHEMAPT
SCHEMBL6748379 0.93 ALDH1A1 (0.39) ALDH1A1TSHRACHETDP1MAPT
SCHEMBL6746674 0.93 ALDH1A1 (0.39) ALDH1A1TSHRACHETDP1MAPT
SCHEMBL6746725 0.93 ALDH1A1 (0.39) ALDH1A1TSHRACHETDP1MAPT
SCHEMBL6748388 0.93 ALDH1A1 (0.39) ALDH1A1TSHRACHETDP1MAPT
SCHEMBL6748989 0.93 ALDH1A1 (0.39) ALDH1A1TSHRACHETDP1MAPT
SCHEMBL6749493 0.89 ADRA2A (0.33) ALDH1A1TSHR
SCHEMBL6748541 0.88 APP (0.36) ALDH1A1TDP1MAPTCYP2C19
SCHEMBL6748752 0.88 APP (0.36) ALDH1A1TDP1MAPTCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6696588-B2 OXIDATION POTENTIAL OF .3-1.5 V ON THE BASIS OF A STANDARD HYDROGEN ELECTRODE, ALKOXY AND AROMATIC AMINE DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-02-24 US disclosed
EP-0861845-B1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL CO (JP) 2003-05-28 EP disclosed
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED 2002-08-22 US disclosed
US-6369258-B1 SILICON COMPOUND WITH OXIDATION POTENTIAL ON HYDROGEN ELECTRODE POTENTIAL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-04-09 US disclosed
EP-0861845-A2 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-09-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same EPCAM, PIEZO1, OR10J3 ALDH1A1 460/4885TSHR 4205/4885ACHE 363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.