Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FEN1 | P39748 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6718990 | 0.87 | SCN9A (0.44) | SCN9APTGES2ALOX5APFEN1RECQL | |
| SCHEMBL6841185 | 0.85 | PTGES2 (0.41) | SCN9APTGES2HTTRECQLTSHR | |
| SCHEMBL6750007 | 0.83 | TGFBR1 (0.42) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL6747196 | 0.82 | CA1 (0.43) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL6746438 | 0.82 | TGFBR1 (0.47) | ALOX5APFEN1CA1CA2TGFBR1 | |
| SCHEMBL6749945 | 0.81 | SCN9A (0.43) | SCN9APTGES2ALOX5APFEN1HTT | |
| SCHEMBL7045462 | 0.81 | SCN9A (0.45) | SCN9AALOX5APFEN1HTTPTGS2 | |
| SCHEMBL6834757 | 0.81 | CA1 (0.45) | SCN9APTGES2CA1CA2PTGS2 | |
| SCHEMBL6720109 | 0.80 | SCN9A (0.39) | SCN9AALOX5APFEN1HTTPDE4A | |
| SCHEMBL6746652 | 0.79 | CA1 (0.40) | ALOX5APFEN1CA1CA2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | claimed |
| US-6699884-B2 | ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. | PHARMACIA CORPORATION | 2004-03-02 | — | — | US | disclosed |