Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.58 |
| ▸ | ACHE | P22303 | 4/20 | 0.58 |
| ▸ | ESR1 | P03372 | 6/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.46 |
| ▸ | CCR4 | P51679 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6746980 | 0.94 | ESR1 (0.51) | BCHEACHEESR1MAOBHRH3 | |
| Hydrochloric Acid SCHEMBL6748793 | 0.91 | ALK (0.51) | BCHEACHEESR1MAOBHRH3 | |
| SCHEMBL6748770 | 0.88 | ESR1 (0.58) | ESR1ESR2 | |
| SCHEMBL8588411 | 0.87 | BCHE (0.60) | BCHEACHEESR1MAOBHRH3 | |
| Hydrochloric Acid SCHEMBL8591894 | 0.87 | BCHE (0.59) | BCHEACHEESR1MAOBHRH3 | |
| Hydrochloric Acid SCHEMBL7112343 | 0.86 | BCHE (0.59) | BCHEACHEESR1MAOBHRH3 | |
| Hydrochloric Acid SCHEMBL6748771 | 0.84 | ESR1 (0.51) | ESR1ESR2 | |
| SCHEMBL7117346 | 0.84 | ALDH1A1 (0.53) | BCHEACHEMAOBKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6749953 | 0.83 | ESR1 (0.52) | ESR1ESR2 | |
| SCHEMBL6748926 | 0.83 | ESR1 (0.49) | BCHEACHEESR1HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6703407-B1 | TREATMENT OF MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION | ELI LILLY AND COMPANY | 2004-03-09 | — | — | US | disclosed |
| EP-0774966-B1 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | LILLY CO ELI (US) | 2003-11-05 | — | — | EP | disclosed |
| EP-0774966-A4 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | LILLY CO ELI (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0774966-A1 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | ELI LILLY AND COMPANY (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996009040-A1 | BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS | ELI LILLY AND COMPANY (US) | 1996-03-28 | — | — | WO | disclosed |