Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Aniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | LAP3 | P28838 | 3/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aniline SCHEMBL5334646 | 1.00 | TSHR (0.65) | TSHRCA2CA4CA5APBRM1 | |
| Aniline SCHEMBL321169 | 1.00 | TSHR (0.65) | TSHRCA2CA4CA5APBRM1 | |
| Aniline SCHEMBL29573098 | 1.00 | TSHR (0.65) | TSHRCA2CA4CA5APBRM1 | |
| Aniline SCHEMBL28659856 | 0.97 | TSHR (0.61) | TSHRCA2CA4CA5APBRM1 | |
| Aniline SCHEMBL1533980 | 0.97 | TSHR (0.61) | TSHRCA2CA4CA5APBRM1 | |
| Aniline SCHEMBL28661396 | 0.97 | TSHR (0.61) | TSHRCA2CA4CA5APBRM1 | |
| Aniline SCHEMBL28663674 | 0.97 | TSHR (0.61) | TSHRCA2CA4CA5APBRM1 | |
| Aniline SCHEMBL8683062 | 0.92 | TSHR (0.61) | TSHRCA2CA4CA5APBRM1 | |
| Aniline SCHEMBL6538352 | 0.90 | TSHR (0.52) | TSHRCA2CA4CA5APBRM1 | |
| Aniline SCHEMBL28527754 | 0.90 | TSHR (0.52) | TSHRCA2CA4CA5APBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116323817-A | Powder composition, coating film and three-dimensional molded article | 大金工业株式会社 | 2023-06-23 | — | — | CN | disclosed |
| CN-113563138-A | Method for reducing soil nitrogen emission and nitrogen emission inhibitor used by same | 浙江省农业科学院 | 2021-10-29 | — | — | CN | disclosed |
| CN-104854224-B | Lubricating grease composition for improving low-temperature fretting | 协同油脂株式会社 | 2020-03-24 | — | — | CN | disclosed |
| EP-2920148-B1 | PICTET-SPENGLER LIGATION FOR PROTEIN CHEMICAL MODIFICATION | UNIV CALIFORNIA (US) | 2019-06-12 | — | — | EP | disclosed |
| US-9605078-B2 | Pictet-Spengler ligation for protein chemical modification | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150291699-A1 | PICTET-SPENGLER LIGATION FOR PROTEIN CHEMICAL MODIFICATION | GERAWAN FARMING LLC | 2015-10-15 | — | — | US | disclosed |
| EP-2920148-A1 | PICTET-SPENGLER LIGATION FOR PROTEIN CHEMICAL MODIFICATION | The Regents of The University of California (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014078733-A1 | PICTET-SPENGLER LIGATION FOR PROTEIN CHEMICAL MODIFICATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-05-22 | — | — | WO | disclosed |
| US-7968009-B2 | Electrically conductive nanocomposite particles having a polyalkyl acrylate core and a polyaniline coating | UPPA-UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR (FR) | 2011-06-28 | — | — | US | disclosed |
| US-20090212263-A1 | ELECTRICALLY CONDUCTIVE NANOCOMPOSITE PARTICLES HAVING A POLYALKYL ACRYLATE CORE AND A POLYANILINE COATING | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291699-A1 | PICTET-SPENGLER LIGATION FOR PROTEIN CHEMICAL MODIFICATION | PTMS, SHMT1, OGA | TSHR 1153/4885CA2 1936/4885CA4 890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.