SCHEMBL6750841

SCHEMBL6750841

O=C1CN(Cc2cccc(Oc3ccc(Cl)c(Cl)c3)c2)C(=O)N1CCC1CCCCN1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.39
NPY1R P25929 2/20 0.37
DRD2 P14416 2/20 0.36
DRD3 P35462 2/20 0.36
KCNH2 Q12809 2/20 0.36
HTR1A P08908 1/20 0.36
CYP2D6 P10635 1/20 0.36
HTR1D P28221 1/20 0.36
HTR2A P28223 1/20 0.36
HRH1 P35367 1/20 0.36
ADRA1B P35368 1/20 0.36
LTA4H P09960 4/20 0.36
LMNA P02545 1/20 0.35
ADRA1A P35348 1/20 0.34
ALDH1A1 P00352 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5672388 0.90 LTA4H (0.43) LTA4HALDH1A1
SCHEMBL5672025 0.86 LTA4H (0.47) FAAHDRD2DRD3KCNH2LTA4H
SCHEMBL5669916 0.83 KCNH2 (0.41) FAAHNPY1RKCNH2LTA4HLMNA
SCHEMBL5670000 0.81 LTA4H (0.49) NPY1RLTA4HLMNAALDH1A1
SCHEMBL6750843 0.81 FAAH (0.45) FAAHDRD2DRD3KCNH2LMNA
SCHEMBL6750833 0.79 NPY1R (0.47) NPY1RLTA4H
SCHEMBL6750846 0.79 SLC6A3 (0.41) FAAH
SCHEMBL5406376 0.76 MAPT (0.43) NPY1RLTA4H
SCHEMBL5397997 0.73 MAPT (0.43)
SCHEMBL5672391 0.70 KDM4E (0.49) FAAHDRD2DRD3HRH1ADRA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040097569-A1 Aryl substituted hydantoin compounds and their use as sodium channel blockers EURO-CELTIQUE S.A. 2004-05-20 US claimed
US-20040097569-A1 Aryl substituted hydantoin compounds and their use as sodium channel blockers EURO-CELTIQUE S.A. 2004-05-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040097569-A1 Aryl substituted hydantoin compounds and their use as sodium channel blockers SCN1A, CACNA1S, SCN1B FAAH 254/4885NPY1R 1069/4885DRD2 913/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.