Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | NOS2 | P35228 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 6/20 | 0.34 |
| ▸ | MAP3K8 | P41279 | 3/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6746261 | 0.99 | CYP2D6 (0.37) | CYP2D6SLC6A2SLC6A4NOS2EGFR | |
| SCHEMBL6189779 | 0.82 | CYP3A4 (0.36) | CYP2D6SLC6A2SLC6A4NOS2KDM4E | |
| SCHEMBL6185674 | 0.81 | CYP2D6 (0.38) | CYP2D6SLC6A2SLC6A4NOS2KDM4E | |
| Hydrochloric Acid SCHEMBL6748191 | 0.81 | CYP3A4 (0.36) | CYP2D6SLC6A2SLC6A4NOS2KDM4E | |
| Hydrochloric Acid SCHEMBL6752561 | 0.80 | CYP2D6 (0.37) | CYP2D6SLC6A2SLC6A4NOS2KDM4E | |
| SCHEMBL6748032 | 0.79 | NOS2 (0.55) | CYP2D6SLC6A2SLC6A4NOS2EGFR | |
| Hydrochloric Acid SCHEMBL6855357 | 0.78 | NOS2 (0.54) | CYP2D6SLC6A2SLC6A4NOS2EGFR | |
| Hydrochloric Acid SCHEMBL6855347 | 0.78 | NOS2 (0.54) | CYP2D6SLC6A2SLC6A4NOS2EGFR | |
| SCHEMBL6750114 | 0.76 | S1PR1 (0.32) | CYP2D6SLC6A2SLC6A4NOS2S1PR1 | |
| SCHEMBL6750137 | 0.74 | NOS2 (0.49) | CYP2D6SLC6A2SLC6A4NOS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242871-A1 | Novel arylheteroalkylamine derivatives | ASTRAZENECA AB (SE) | 2004-12-02 | — | — | US | claimed |
| US-20040242871-A1 | Novel arylheteroalkylamine derivatives | ASTRAZENECA AB (SE) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242871-A1 | Novel arylheteroalkylamine derivatives | CYP1A1, NOS3, NOS1 | CYP2D6 48/4885SLC6A2 2580/4885SLC6A4 1815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.