Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13855361 | 0.84 | MEN1 (0.51) | MAOAMAOBMAPTLMNAKDM4E | |
| SCHEMBL6752550 | 0.79 | TDP1 (0.50) | MAOAMAOBEGFRMMP1MMP2 | |
| SCHEMBL6752558 | 0.78 | CYP2C9 (0.43) | LMNAALDH1A1GAAHPGD | |
| SCHEMBL6752276 | 0.78 | CYP2C9 (0.43) | LMNAALDH1A1GAAHPGD | |
| SCHEMBL14205237 | 0.73 | MAOA (0.56) | MAOAMAOBBACE1EGFRMMP1 | |
| SCHEMBL2440214 | 0.72 | IAPP (0.62) | MAOAMAOBEGFRMMP1MMP2 | |
| SCHEMBL13287417 | 0.72 | IAPP (0.62) | MAOAMAOBEGFRMMP1MMP2 | |
| SCHEMBL2441249 | 0.72 | IAPP (0.62) | MAOAMAOBEGFRMMP1MMP2 | |
| SCHEMBL27832635 | 0.72 | IAPP (0.62) | MAOAMAOBEGFRMMP1MMP2 | |
| SCHEMBL3360114 | 0.72 | IAPP (0.58) | MAOAMAOBBACE1EGFRMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183415-B2 | Methods of synthesizing cinacalcet and salts thereof | AMGEN, INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20110281954-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | AMGEN INC. | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281954-A1 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF | ACE, SI, REN | MAOA 4639/4885MAOB 4657/4885BACE1 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.