Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 1/20 | 0.67 |
| ▸ | CDK1 | P06493 | 9/20 | 0.66 |
| ▸ | MTOR | P42345 | 8/20 | 0.66 |
| ▸ | SMG1 | Q96Q15 | 7/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.65 |
| ▸ | BCR | P11274 | 2/20 | 0.65 |
| ▸ | SRC | P12931 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | PRKACA | P17612 | 1/20 | 0.65 |
| ▸ | PRKACG | P22612 | 1/20 | 0.65 |
| ▸ | PRKACB | P22694 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 8/20 | 0.65 |
| ▸ | IKBKB | O14920 | 3/20 | 0.64 |
| ▸ | PLK1 | P53350 | 1/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 1/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471938 | 0.87 | ABL1 (0.70) | CDK1MTORSMG1ABL1BCR | |
| SCHEMBL823915 | 0.86 | CAMK2D (0.82) | CAMK2DABL1BCRSRCEGFR | |
| SCHEMBL7524252 | 0.86 | CDK1 (0.69) | CDK1MTORSMG1ABL1BCR | |
| SCHEMBL6752978 | 0.85 | CDK1 (0.66) | CDK1MTORSMG1ABL1BCR | |
| SCHEMBL1667404 | 0.84 | IKBKB (0.62) | CDK1MTORSMG1CDK2IKBKB | |
| SCHEMBL3518683 | 0.83 | IKBKB (0.66) | CDK1MTORSMG1ABL1CDK2 | |
| SCHEMBL27444270 | 0.82 | PLK1 (0.78) | CAMK2DSMG1ABL1BCRSRC | |
| SCHEMBL3521890 | 0.82 | CDK1 (0.62) | CDK1MTORSMG1CDK2IKBKB | |
| SCHEMBL14253959 | 0.82 | IKBKB (0.67) | CDK1MTORSMG1ABL1CDK2 | |
| SCHEMBL7464681 | 0.81 | CDK1 (0.61) | CDK1MTORSMG1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147507-A1 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147507-A1 | Compositions useful as inhibitors of JAK and other protein kinases | JAK1, JAK2, JAK3 | CAMK2D 442/4885CDK1 113/4885MTOR 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.