Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 13/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.61 |
| ▸ | CDK9 | P50750 | 8/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | BCR | P11274 | 1/20 | 0.61 |
| ▸ | PRKCA | P17252 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 8/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.61 |
| ▸ | CDK7 | P50613 | 4/20 | 0.61 |
| ▸ | CCNH | P51946 | 4/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.61 |
| ▸ | IKBKB | O14920 | 2/20 | 0.60 |
| ▸ | MTOR | P42345 | 6/20 | 0.60 |
| ▸ | SMG1 | Q96Q15 | 5/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469285 | 0.86 | IKBKB (0.74) | CDK1CCNT1CCNB1CDK9CDK2 | |
| SCHEMBL7524252 | 0.83 | CDK1 (0.69) | CDK1CCNT1CCNB1CDK9ABL1 | |
| SCHEMBL30557958 | 0.83 | ROCK1 (0.61) | CDK1CCNT1CCNB1CDK9CDK2 | |
| SCHEMBL7471938 | 0.82 | ABL1 (0.70) | CDK1CCNT1CCNB1CDK9ABL1 | |
| SCHEMBL3520990 | 0.81 | CDK1 (0.66) | CDK1CCNT1CCNB1CDK9CDK2 | |
| SCHEMBL6752979 | 0.81 | CAMK2D (0.67) | CDK1CCNT1CCNB1CDK9ABL1 | |
| SCHEMBL4903508 | 0.81 | ABL1 (0.67) | ABL1BCRPRKCACDK2SYK | |
| SCHEMBL6752978 | 0.81 | CDK1 (0.66) | CDK1CCNT1CCNB1CDK9ABL1 | |
| SCHEMBL3518683 | 0.80 | IKBKB (0.66) | CDK1CCNT1CCNB1CDK9ABL1 | |
| SCHEMBL4153552 | 0.80 | SYK (0.67) | CDK1CCNT1CCNB1CDK9CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |