Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.62 |
| ▸ | CDK1 | P06493 | 10/20 | 0.62 |
| ▸ | MTOR | P42345 | 8/20 | 0.62 |
| ▸ | SMG1 | Q96Q15 | 7/20 | 0.62 |
| ▸ | CDK2 | P24941 | 8/20 | 0.61 |
| ▸ | CHUK | O15111 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 2/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.55 |
| ▸ | CDK9 | P50750 | 3/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.55 |
| ▸ | CDK7 | P50613 | 2/20 | 0.55 |
| ▸ | CCNH | P51946 | 2/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | DKK1 | O94907 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752979 | 0.84 | CAMK2D (0.67) | IKBKBCDK1MTORSMG1CDK2 | |
| SCHEMBL7471938 | 0.83 | ABL1 (0.70) | IKBKBCDK1MTORSMG1CDK2 | |
| SCHEMBL1667082 | 0.83 | SYK (0.60) | IKBKBSMG1CDK2CHUKPIK3CG | |
| SCHEMBL7524252 | 0.82 | CDK1 (0.69) | IKBKBCDK1MTORSMG1CDK2 | |
| SCHEMBL6752978 | 0.82 | CDK1 (0.66) | IKBKBCDK1MTORSMG1CDK2 | |
| SCHEMBL12275024 | 0.81 | IKBKB (0.58) | IKBKBCDK1MTORSMG1CDK2 | |
| SCHEMBL6508664 | 0.81 | CAMK2D (0.69) | CDK1MTORSMG1CDK2SYK | |
| SCHEMBL1667452 | 0.81 | SYK (0.58) | IKBKBSMG1CDK2CHUKSYK | |
| SCHEMBL12448809 | 0.81 | SYK (0.55) | IKBKBSMG1CDK2CHUKSYK | |
| SCHEMBL12275241 | 0.80 | PLK1 (0.61) | IKBKBSMG1CDK2CHUKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | MYREXIS, INC. (US) | 2012-09-20 | — | — | US | claimed |
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | claimed |
| US-20150352108-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON | ALZHEIMER'S INSTITUTE OF AMERICA (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150352108-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON | ALZHEIMER'S INSTITUTE OF AMERICA (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150352108-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON | ALZHEIMER'S INSTITUTE OF AMERICA (US) | 2015-12-10 | — | — | US | disclosed |
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | MYREXIS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150352108-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON | TBK1, NFKBIA, CHUK | IKBKB 6/4885CDK1 157/4885MTOR 67/4885 |
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | TBK1, NFKBIA, IKBKB | IKBKB 3/4885CDK1 312/4885MTOR 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.