Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.41 |
| ▸ | MARS1 | P56192 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6755918 | 0.91 | HINT1 (0.43) | HINT1ADORA2ANT5EADORA3ADORA2B | |
| SCHEMBL6242507 | 0.81 | HINT1 (0.50) | HINT1NT5E | |
| SCHEMBL30324459 | 0.80 | ADORA3 (0.54) | ADORA2AADORA3ADORA2B | |
| SCHEMBL6242581 | 0.79 | HINT1 (0.48) | HINT1NT5E | |
| SCHEMBL6241689 | 0.79 | HINT1 (0.48) | HINT1ADORA2ANT5EADORA2B | |
| SCHEMBL6243042 | 0.78 | HINT1 (0.50) | HINT1NT5E | |
| SCHEMBL14896399 | 0.77 | HINT1 (0.49) | HINT1ADORA2ANT5E | |
| SCHEMBL30324473 | 0.75 | ADORA1 (0.55) | ADORA2AADORA3ADORA2B | |
| SCHEMBL12223717 | 0.74 | NT5E (0.43) | ADORA2ANT5EADORA3ADORA2B | |
| SCHEMBL12667512 | 0.74 | NT5E (0.43) | ADORA2ANT5EADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409731-A2 | METHODS OF MODULATING PHARMACOKINETICS OF OLIGONUCLEOTIDES | ISIS Pharmaceuticals, Inc. (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003004603-A2 | METHODS OF MODULATING PHARMACOKINETICS OF OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 2003-01-16 | — | — | WO | disclosed |