Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.57 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 7/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 6/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.36 |
| ▸ | MGMT | P16455 | 3/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL29217335 | 0.90 | PNP (0.77) | PNPGDADPP4KDM4EMEN1 | |
| 2,6-Diaminopurine SCHEMBL1825533 | 0.88 | PNP (0.79) | PNPPDPK1GDADPP4KDM4E | |
| Thioguanine SCHEMBL27562480 | 0.84 | PNP (0.62) | PNPPDPK1GDADPP4KDM4E | |
| 8-Azaguanine SCHEMBL26817 | 0.79 | PNP (0.61) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL28330713 | 0.78 | PNP (0.93) | PNPPDPK1GDADPP4KDM4E | |
| Guanine SCHEMBL986801 | 0.78 | PNP (1.00) | PNPPDPK1GDADPP4KDM4E | |
| Guanine SCHEMBL5260 | 0.78 | PNP (1.00) | PNPPDPK1GDADPP4KDM4E | |
| Guanine SCHEMBL1264884 | 0.78 | PNP (1.00) | PNPPDPK1GDADPP4KDM4E | |
| Guanine SCHEMBL9511597 | 0.76 | PNP (0.96) | PNPPDPK1GDADPP4KDM4E | |
| Guanine SCHEMBL22533907 | 0.76 | PNP (0.96) | PNPPDPK1GDADPP4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004053168-A1 | MODULATION OF ADIPOPHILIN EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2004-06-24 | — | — | WO | disclosed |