Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.79 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.70 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.70 |
| ▸ | DPP4 | P27487 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL28330713 | 0.89 | PNP (0.93) | PNPGDAPDPK1DPP4ALDH1A1 | |
| Guanine SCHEMBL5260 | 0.89 | PNP (1.00) | PNPGDAPDPK1DPP4ALDH1A1 | |
| Guanine SCHEMBL986801 | 0.89 | PNP (1.00) | PNPGDAPDPK1DPP4ALDH1A1 | |
| Guanine SCHEMBL1264884 | 0.89 | PNP (1.00) | PNPGDAPDPK1DPP4ALDH1A1 | |
| 2,6-Diaminopurine SCHEMBL6755680 | 0.88 | PNP (0.61) | PNPGDAPDPK1DPP4ALDH1A1 | |
| Guanine SCHEMBL2895089 | 0.87 | PNP (0.96) | PNPGDAPDPK1DPP4ALDH1A1 | |
| Guanine SCHEMBL9511597 | 0.87 | PNP (0.96) | PNPGDAPDPK1DPP4ALDH1A1 | |
| Guanine SCHEMBL19436607 | 0.87 | PNP (0.96) | PNPGDAPDPK1DPP4ALDH1A1 | |
| Guanine SCHEMBL22533907 | 0.87 | PNP (0.96) | PNPGDAPDPK1DPP4ALDH1A1 | |
| Guanine SCHEMBL21611718 | 0.87 | PNP (0.96) | PNPGDAPDPK1DPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688778-A | VIRICIDES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 1997-11-18 | — | — | US | claimed |
| EP-0968223-B1 | BIOCONJUGATION OF MACROMOLECULES | SIGMA ALDRICH CO LLC (US) | 2016-12-21 | — | — | EP | disclosed |
| EP-2256133-B1 | Bioconjugation of macromolecules | SIGMA ALDRICH CO LLC (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-2319854-B1 | Bioconjugation Of Macromolecules | SIGMA ALDRICH CO LLC (US) | 2016-11-30 | — | — | EP | disclosed |
| EP-2319855-B1 | Bioconjugation of Macromolecules | SIGMA ALDRICH CO LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| EP-2319855-A1 | Bioconjugation of Macromolecules | Sigma-Aldrich Co. (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-2319854-A1 | Bioconjugation Of Macromolecules | Sigma-Aldrich Co. (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-2256133-A1 | Bioconjugation of macromolecules | Sigma-Aldrich Co. (US) | 2010-12-01 | — | — | EP | disclosed |
| US-20040116685-A1 | Method for solution phase synthesis of oligonucleotides | PROLIGO LLC | 2004-06-17 | — | — | US | disclosed |
| US-6737236-B1 | DERIVATIZING OLIGONUCLEOTIDES AND PROTEINS USING CYCLOADDITION REACTIONS INCLUDING DIELS-ALDER REACTION OR 1,3-DIPOLAR CYCLOADDITION REACTIONS | PROLIGO, LLC | 2004-05-18 | — | — | US | disclosed |
| EP-0979233-A1 | METHOD FOR SOLUTION PHASE SYNTHESIS OF OLIGONUCLEOTIDES | NeXstar Pharmaceuticals, Inc. (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0968223-A1 | BIOCONJUGATION OF MACROMOLECULES | Proligo L.L.C. (US) | 2000-01-05 | — | — | EP | disclosed |
| US-6001966-A | REACTING N-TERMINAL PROTECTED AMINO ACID WITH PEPTIDE STARTING MATERIAL FORMING A PEPTIDE PRODUCT, PARTITIONING FROM UNREACTED MATERIAL AND REAGENTS BASED ON PRESENCE OF N-TERMINAL BLOCKING/ANCHORING GROUP | PROLIGO LLC (US) | 1999-12-14 | — | — | US | disclosed |
| US-5874532-A | USING A N-TERMINAL PROTECTED AMINO ACID MONOMER | NEXSTAR PHARMACEUTICALS, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0767657-A4 | NOVEL METHOD OF PREPARATION OF KNOWN AND NOVEL 2'-MODIFIED NUCLEOSIDES BY INTRAMOLECULAR NUCLEOPHILIC DISPLACEMENT | NEXSTAR PHARMACEUTICALS INC (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1998047910-A1 | METHOD FOR SOLUTION PHASE SYNTHESIS OF OLIGONUCLEOTIDES | PROLIGO LLC (US) | 1998-10-29 | — | — | WO | disclosed |
| WO-1998030575-A1 | BIOCONJUGATION OF MACROMOLECULES | PROLIGO LLC (US) | 1998-07-16 | — | — | WO | disclosed |
| WO-1998030578-A1 | METHOD FOR SOLUTION PHASE SYNTHESIS OF OLIGONUCLEOTIDES AND PEPTIDES | PROLIGO LLC (US) | 1998-07-16 | — | — | WO | disclosed |
| EP-0767657-A1 | NOVEL METHOD OF PREPARATION OF KNOWN AND NOVEL 2'-MODIFIED NUCLEOSIDES BY INTRAMOLECULAR NUCLEOPHILIC DISPLACEMENT | NeXstar Pharmaceuticals, Inc. (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1995035102-A1 | NOVEL METHOD OF PREPARATION OF KNOWN AND NOVEL 2'-MODIFIED NUCLEOSIDES BY INTRAMOLECULAR NUCLEOPHILIC DISPLACEMENT | NEXSTAR PHARMACEUTICALS, INC. (US) | 1995-12-28 | — | — | WO | disclosed |