Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.52 |
| ▸ | APBA1 | Q02410 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.52 |
| ▸ | CCR6 | P51684 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9306130 | 0.83 | MEN1 (0.66) | ALDH1A1GAALMNAMEN1KMT2A | |
| SCHEMBL5081647 | 0.81 | MEN1 (0.64) | MAPTALDH1A1NPSR1CACNA1BAPBA1 | |
| SCHEMBL9304659 | 0.81 | MEN1 (0.52) | MAPTALDH1A1GAAALOX12HPGD | |
| SCHEMBL9303944 | 0.75 | MEN1 (0.49) | MAPTALDH1A1NPSR1GAAMEN1 | |
| SCHEMBL17289272 | 0.71 | ALDH1A1 (0.59) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL17796945 | 0.71 | ALDH1A1 (0.59) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL7582583 | 0.70 | MAPT (1.00) | MAPTALDH1A1NPSR1CACNA1BAPBA1 | |
| SCHEMBL16107854 | 0.69 | L3MBTL1 (0.64) | MAPTALDH1A1NPSR1GAAALOX12 | |
| SCHEMBL29211172 | 0.69 | MYC (0.49) | MAPTALDH1A1ALOX12HPGDLMNA | |
| SCHEMBL9282551 | 0.69 | ALDH1A1 (0.52) | MAPTALDH1A1ALOX12HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6719520-B2 | FOR INHIBITION OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3); TREATMENT AND PROPHYLAXIS FOR DIABETES, CHRONIC NEURODEGENERATIVE CONDITIONS, MOOD DISORDERS SUCH AS SCHIZOPHRENIA AND MANIC DEPRESSION AND HAIR LOSS AND CANCER | SMITHKLINE BEECHAM CORPORATION | 2004-04-13 | — | — | US | disclosed |