Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | RECQL | P46063 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 3/20 | 0.51 |
| ▸ | BLM | P54132 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 8/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 8/20 | 0.49 |
| ▸ | UBE2I | P63279 | 3/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676446 | 0.84 | MEN1 (0.45) | MAPTMEN1KMT2ATP53MAPK1 | |
| SCHEMBL676445 | 0.83 | MMP2 (0.42) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| SCHEMBL675639 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4EPOLBMAPTRECQL | |
| SCHEMBL676086 | 0.81 | ALDH1A1 (0.48) | ALDH1A1KDM4EPOLBMAPTRECQL | |
| SCHEMBL675502 | 0.81 | RAB9A (0.47) | ALDH1A1KDM4EPOLBMAPTMEN1 | |
| SCHEMBL674656 | 0.80 | MAPT (0.52) | ALDH1A1KDM4EMAPTHPGDMEN1 | |
| SCHEMBL698444 | 0.78 | SMN1; SMN2 (0.54) | ALDH1A1MAPTRECQLHPGDMEN1 | |
| SCHEMBL676050 | 0.77 | KDM4E (0.48) | ALDH1A1KDM4EHPGDKMT2ALMNA | |
| SCHEMBL675622 | 0.77 | HDAC2 (0.41) | ALDH1A1KDM4EPOLBMAPTHPGD | |
| SCHEMBL675623 | 0.77 | HDAC2 (0.41) | ALDH1A1KDM4EPOLBMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA (IT) | 2011-11-17 | — | — | US | disclosed |
| CN-102203092-A | Alfa-carboline inhibitors of npm-alk, ret, and bcr-abl | UNIV DEGLI STUDI MILANO | 2011-09-28 | — | — | CN | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | ALK, BCR, NPM1 | ALDH1A1 749/4885KDM4E 2789/4885POLB 2689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.