Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264050 | 0.87 | ALDH1A1 (0.65) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6760390 | 0.83 | LMNA (0.57) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22573586 | 0.83 | NPC1 (0.50) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11782992 | 0.82 | MEN1 (0.50) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22573277 | 0.82 | ALDH1A1 (0.47) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22573762 | 0.82 | PRKCI (0.57) | ALDH1A1MEN1KMT2AKDM4EL3MBTL1 | |
| SCHEMBL22573544 | 0.82 | LMNA (0.64) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5736742 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27576873 | 0.81 | MEN1 (0.53) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22712505 | 0.79 | NPC1 (0.50) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1296346-C | Acylated 6,7,8,9-tetrahydro-5H-benzocycloheptenyl amines and their use as pharmaceutical | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-01-24 | — | — | CN | disclosed |
| US-6759412-B2 | FOR PRODUCING DRUGS USED FOR THERAPY OF CARDIOVASCULAR DISEASES, STABLE OR UNSTABLE ANGINA PECTORIS, CORONARY HEART DISEASE, PRINZMETAL ANGINA, ACUTE CORONARY SYNDROME, HEART FAILURE, MYOCARDIAL INFARCTION, STROKE, THROMBOSIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-06 | — | — | US | disclosed |
| CN-1491208-A | Acylated 6,7,8,9-tetrahydro-5H-benzocycloheptenyl amines and their use as pharmaceutical | ������ҽҩ�¹�����˾ | 2004-04-21 | — | — | CN | disclosed |