Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 6/20 | 0.41 |
| ▸ | ITGB6 | P18564 | 5/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763765 | 0.95 | ITGAV (0.43) | ITGAVITGB6ITGB3ITGB5ITGA5 | |
| Trifluoroacetic Acid SCHEMBL6763147 | 0.89 | ITGAV (0.49) | ITGAVITGB6ITGB3ITGB5ITGA5 | |
| SCHEMBL6762454 | 0.86 | ITGAV (0.41) | ITGAVITGB6ITGB3ITGB5ITGA5 | |
| SCHEMBL6767502 | 0.85 | ITGAV (0.42) | ITGAVITGB6ITGB3ITGB5ITGA5 | |
| Trifluoroacetic Acid SCHEMBL6763757 | 0.84 | ITGAV (0.53) | ITGAVITGB6ITGB3ITGB5ITGA5 | |
| SCHEMBL6762908 | 0.83 | ITGAV (0.54) | ITGAVITGB6ITGB3ITGB5ITGA5 | |
| SCHEMBL5845774 | 0.81 | KCNH2 (0.43) | ITGAVITGB6ITGB3ITGB5ITGA5 | |
| Trifluoroacetic Acid SCHEMBL6764609 | 0.81 | ITGAV (0.49) | ITGAVITGB6ITGB3ITGB5ITGA5 | |
| SCHEMBL5844920 | 0.80 | BCHE (0.44) | ITGAVITGB6ITGB3ITGB5ITGA5 | |
| SCHEMBL6760476 | 0.80 | ITGAV (0.48) | ITGAVITGB6ITGB3ITGB5ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040010023-A1 | Biphenyl derivatives and the use thereof as integrin inhibitors | MERCK PATENT GMBH (DE) | 2004-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040010023-A1 | Biphenyl derivatives and the use thereof as integrin inhibitors | ITGB1, ITGB4, ITGB3 | ITGAV 16/4885ITGB6 10/4885ITGB3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.