Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.52 |
| ▸ | DRD4 | P21917 | 7/20 | 0.52 |
| ▸ | DRD3 | P35462 | 6/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766482 | 0.85 | DRD4 (0.50) | DRD2DRD4DRD3OPRL1OPRM1 | |
| Hydrochloric Acid SCHEMBL6763540 | 0.84 | DRD4 (0.49) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL6763493 | 0.82 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1TDP1KDM4ECHRM2 | |
| Hydrochloric Acid SCHEMBL6766287 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1KDM4ECHRM2CHRM3 | |
| SCHEMBL2983878 | 0.70 | OPRL1 (0.59) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL5778501 | 0.69 | MAPT (0.42) | DRD3SMN1; SMN2ALDH1A1HIF1ATDP1 | |
| Hydrochloric Acid SCHEMBL5780693 | 0.68 | MAPT (0.41) | DRD3SMN1; SMN2ALDH1A1HIF1ATDP1 | |
| SCHEMBL6195713 | 0.67 | DRD4 (0.59) | DRD2DRD4DRD3SIGMAR1ACHE | |
| SCHEMBL2710149 | 0.67 | ACHE (0.57) | DRD2DRD4DRD3SIGMAR1ACHE | |
| SCHEMBL6763402 | 0.66 | MAOB (0.43) | CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | claimed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |