Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 18/20 | 0.50 |
| ▸ | DRD2 | P14416 | 17/20 | 0.50 |
| ▸ | DRD3 | P35462 | 17/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6763540 | 0.99 | DRD4 (0.49) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL6763428 | 0.85 | DRD2 (0.52) | DRD4DRD2DRD3OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL6772679 | 0.85 | DRD2 (0.51) | DRD4DRD2DRD3OPRM1OPRK1 | |
| SCHEMBL6772713 | 0.83 | MAOB (0.41) | CHRM2CHRM3 | |
| SCHEMBL6763603 | 0.82 | MAOB (0.45) | — | |
| Hydrochloric Acid SCHEMBL6766030 | 0.81 | MAOB (0.41) | DRD2CHRM2CHRM3 | |
| SCHEMBL6763525 | 0.81 | CES2 (0.46) | — | |
| SCHEMBL6763402 | 0.80 | MAOB (0.43) | CHRM2 | |
| SCHEMBL6763481 | 0.75 | MAOB (0.41) | — | |
| SCHEMBL2983878 | 0.75 | OPRL1 (0.59) | DRD4DRD2DRD3OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | claimed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |