Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 11/20 | 0.65 |
| ▸ | CNR1 | P21554 | 10/20 | 0.65 |
| ▸ | ACHE | P22303 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763443 | 1.00 | CNR2 (0.65) | CNR2CNR1ACHEKDM4EGUCY1B2 | |
| SCHEMBL6767172 | 0.72 | CNR2 (0.68) | CNR2CNR1ACHEKDM4EGUCY1B2 | |
| SCHEMBL12913004 | 0.71 | BCHE (0.43) | CNR2CNR1ACHEBCHEPPARG | |
| SCHEMBL9917403 | 0.70 | CNR2 (0.81) | CNR2CNR1ACHEKDM4EGUCY1B2 | |
| SCHEMBL9042355 | 0.68 | CNR2 (0.60) | CNR2CNR1ACHEKDM4EGUCY1B2 | |
| SCHEMBL6764408 | 0.68 | CNR2 (0.65) | CNR2CNR1ACHEKDM4EGUCY1B2 | |
| SCHEMBL9917500 | 0.68 | CNR2 (1.00) | CNR2CNR1ACHEKDM4EGUCY1B2 | |
| SCHEMBL12092607 | 0.67 | CNR2 (0.76) | CNR2CNR1ACHEKDM4EGUCY1B2 | |
| SCHEMBL12913014 | 0.67 | CNR2 (0.70) | CNR2CNR1ACHEKDM4EGUCY1B2 | |
| SCHEMBL7811883 | 0.67 | CNR2 (0.58) | CNR2CNR1ACHEKDM4EGUCY1B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040048866-A1 | Indazole derivatives that are activators of soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-03-11 | — | — | US | claimed |
| US-20040048866-A1 | Indazole derivatives that are activators of soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048866-A1 | Indazole derivatives that are activators of soluble guanylate cyclase | GUCY1B1, GUCY1A1, GUCY1A2 | CNR2 1561/4885CNR1 1179/4885ACHE 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.