Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.68 |
| ▸ | CNR1 | P21554 | 6/20 | 0.68 |
| ▸ | ACHE | P22303 | 4/20 | 0.68 |
| ▸ | PDE5A | O76074 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8007567 | 0.91 | CNR2 (0.68) | CNR2CNR1ACHEPDE5AKDM4E | |
| SCHEMBL6764408 | 0.86 | CNR2 (0.65) | CNR2CNR1ACHEPDE5AKDM4E | |
| SCHEMBL6763450 | 0.81 | CNR2 (0.58) | CNR2CNR1ACHEPDE5AKDM4E | |
| SCHEMBL6764379 | 0.79 | PDE5A (0.62) | CNR2CNR1ACHEPDE5AKDM4E | |
| SCHEMBL6761965 | 0.78 | CNR2 (0.54) | CNR2CNR1ACHEKDM4ECYP1A2 | |
| SCHEMBL6762827 | 0.76 | SPHK2 (0.50) | CNR2CNR1ACHENPC1RAB9A | |
| SCHEMBL6767192 | 0.76 | CNR2 (0.51) | CNR2CNR1ACHEALDH1A1LMNA | |
| SCHEMBL6766646 | 0.75 | KDM4E (0.54) | CNR2CNR1ACHEKDM4ECYP1A2 | |
| SCHEMBL3076501 | 0.74 | PDE5A (0.66) | CNR2CNR1ACHEPDE5AKDM4E | |
| SCHEMBL9917403 | 0.73 | CNR2 (0.81) | CNR2CNR1ACHEKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040048866-A1 | Indazole derivatives that are activators of soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-03-11 | — | — | US | claimed |
| US-20040048866-A1 | Indazole derivatives that are activators of soluble guanylate cyclase | ABBOTT LABORATORIES | 2004-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048866-A1 | Indazole derivatives that are activators of soluble guanylate cyclase | GUCY1B1, GUCY1A1, GUCY1A2 | CNR2 1561/4885CNR1 1179/4885ACHE 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.