Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307528 | 0.82 | MAPT (0.36) | KDM4EMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6764396 | 0.82 | MAPT (0.37) | KDM4EMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL6767136 | 0.82 | MAPT (0.36) | AKR1B1KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6766773 | 0.76 | MAPT (0.33) | AKR1B1KDM4EMAPTALDH1A1GAA | |
| SCHEMBL5984202 | 0.71 | FNTA (0.42) | KDM4EMAPTSMN1; SMN2MEN1LMNA | |
| SCHEMBL6773459 | 0.71 | KDM4E (0.35) | AKR1B1KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6768867 | 0.71 | CYP3A4 (0.38) | VCAM1CYP3A4 | |
| SCHEMBL7853750 | 0.70 | GABBR2 (0.49) | ALDH1A1GAANPSR1TDP1CYP1A2 | |
| SCHEMBL6308031 | 0.69 | CYP3A4 (0.44) | KDM4EMAPTALDH1A1SMN1; SMN2GAA | |
| Methoxymethane SCHEMBL27439178 | 0.69 | TUBB4A (0.35) | KDM4EMAPTALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686389-B2 | KIDNEY DISEASE, ORGAN TRANSPLANT | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-02-03 | — | — | US | disclosed |
| US-20020156296-A1 | 2,3-dihydrobenzofuran derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-10-24 | — | — | US | disclosed |
| US-6403639-B1 | POTENT CYTOPROTECTIVE AGENT WHICH INHIBITS LIPID-PEROXIDATION FOR PREVENTION AND TREATMENT OF VARIOUS RENAL DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-0995437-A1 | 2,3-DIHYDROBENZOFURAN DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156296-A1 | 2,3-dihydrobenzofuran derivatives | CBR1, CYP2F1, NDUFAF2 | AKR1B1 124/4885KDM4E 4048/4885MAPT 4260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.