Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 4/20 | 0.49 |
| ▸ | MMP13 | P45452 | 3/20 | 0.49 |
| ▸ | MMP1 | P03956 | 2/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6764641 | 0.88 | MAPT (0.54) | PRMT1KMT2AMEN1CA12CA1 | |
| SCHEMBL6767619 | 0.88 | CYP2C19 (0.55) | LMNAKMT2AMEN1HPGDCA12 | |
| SCHEMBL6764633 | 0.88 | NPC1 (0.52) | LMNAKMT2AMEN1HPGDCYP3A4 | |
| SCHEMBL6768091 | 0.87 | MAPT (0.53) | LMNAKMT2AMEN1CYP3A4CYP2C9 | |
| SCHEMBL6764893 | 0.87 | PTGS1 (0.50) | PRMT1KMT2AMEN1HPGDCYP3A4 | |
| SCHEMBL6768704 | 0.87 | CYP2C19 (0.50) | KMT2AMEN1HPGDCYP3A4CYP2C9 | |
| SCHEMBL6764678 | 0.85 | ENPP1 (0.53) | LMNAKMT2AMEN1CA1CA2 | |
| SCHEMBL6764878 | 0.85 | TP53 (0.56) | LMNAKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL27402220 | 0.84 | PRMT1 (0.48) | PRMT1LMNAKMT2AMEN1HPGD | |
| SCHEMBL6768715 | 0.83 | KDM4E (0.57) | KMT2AHPGDCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716844-B2 | ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS | PHARMACIA CORPORATION | 2004-04-06 | — | — | US | disclosed |
| EP-0984959-B1 | AROMATIC SULFONYL ALPHA-HYDROXY HYDROXAMIC ACID COMPOUNDS | PHARMACIA CORP (US) | 2003-09-24 | — | — | EP | disclosed |
| US-20020173508-A1 | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds | PHARMACIA CORPORATION | 2002-11-21 | — | — | US | disclosed |
| US-6362183-B1 | PROTEASE INHIBITORS; RHEUMATIC DISEASES; ANTITUMOR AGENTS | G. D. SEARLE & COMPANY | 2002-03-26 | — | — | US | disclosed |
| EP-0984959-A4 | AROMATIC SULFONYL ALPHA-HYDROXY HYDROXAMIC ACID COMPOUNDS | MONSANTO CO (US) | 2001-05-02 | — | — | EP | disclosed |
| EP-0984959-A1 | AROMATIC SULFONYL ALPHA-HYDROXY HYDROXAMIC ACID COMPOUNDS | MONSANTO COMPANY (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998039326-A1 | AROMATIC SULFONYL ALPHA-HYDROXY HYDROXAMIC ACID COMPOUNDS | MONSANTO COMPANY (US) | 1998-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173508-A1 | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds | MMP1, MMP2, MMP3 | PRMT1 4132/4885LMNA 1455/4885KMT2A 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.