Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 11/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 9/20 | 0.37 |
| ▸ | NOS3 | P29474 | 8/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767585 | 0.89 | RXRA (0.50) | NOS2RXRARXRBRXRGNOS1 | |
| SCHEMBL6164330 | 0.85 | RXRA (0.46) | NOS2RXRARXRBRXRGNOS1 | |
| SCHEMBL6762997 | 0.82 | MIF (0.39) | — | |
| SCHEMBL6166695 | 0.81 | NOS2 (0.45) | NOS2NOS1NOS3 | |
| SCHEMBL6164525 | 0.81 | NOS2 (0.39) | NOS2NOS1NOS3TLR8 | |
| SCHEMBL13040655 | 0.80 | NOS2 (0.38) | NOS2NOS1NOS3TLR8 | |
| SCHEMBL6167004 | 0.80 | NOS2 (0.38) | NOS2NOS1NOS3TLR8 | |
| SCHEMBL13040656 | 0.80 | NOS2 (0.55) | NOS2NOS1NOS3 | |
| SCHEMBL5672155 | 0.79 | NOS2 (0.36) | NOS2NOS1NOS3 | |
| SCHEMBL8329772 | 0.79 | NOS2 (0.39) | NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727239-B1 | INHIBITORY ACTIVITY ON NO- SYNTHASE ENZYMES PRODUCING NITROGEN MONOXIDE NO AND/OR AN ACTIVITY WHICH TRAPS THE REACTIVE OXYGEN SPECIES (ROS) | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-04-27 | — | — | US | disclosed |