Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 4/20 | 0.34 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.34 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 4/20 | 0.34 |
| ▸ | MC5R | P33032 | 4/20 | 0.34 |
| ▸ | MC3R | P41968 | 4/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL675914 | 0.90 | NFE2L2 (0.40) | ALK | |
| SCHEMBL3728950 | 0.88 | GABRP (0.39) | ALKIP6K1IP6K3IP6K2 | |
| SCHEMBL3728948 | 0.88 | GABRP (0.39) | ALKIP6K1IP6K3IP6K2 | |
| SCHEMBL677053 | 0.88 | ALK (0.39) | ALK | |
| SCHEMBL677178 | 0.83 | SGK1 (0.40) | MAOAHRH1 | |
| SCHEMBL675098 | 0.79 | IP6K1 (0.36) | ALKIP6K1IP6K3IP6K2MC4R | |
| SCHEMBL676275 | 0.78 | ALK (0.46) | ALKIP6K1IP6K3IP6K2MC4R | |
| SCHEMBL3728418 | 0.78 | NFE2L2 (0.38) | ALK | |
| SCHEMBL3723526 | 0.77 | TUBB4A (0.45) | ALK | |
| SCHEMBL3723528 | 0.77 | TUBB4A (0.45) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA (IT) | 2011-11-17 | — | — | US | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281862-A1 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | ALK, BCR, NPM1 | ALK 1/4885MAOA 4462/4885IP6K1 3330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.