Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | UGCG | Q16739 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6766907 | 0.85 | PTGS1 (0.50) | PTGS1PTGS2GAAUGCGPDE4A | |
| SCHEMBL10636445 | 0.80 | SHMT2 (0.43) | PTGS1PTGS2GAAPDE4APDE4B | |
| SCHEMBL5778908 | 0.79 | PTGS1 (0.46) | PTGS1PTGS2GAAUGCGPDE4A | |
| SCHEMBL10630259 | 0.78 | GAA (0.49) | PTGS1GAAALDH1A1SMN1; SMN2POLB | |
| SCHEMBL10630291 | 0.76 | MAOB (0.43) | PTGS1GAAMAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL6763490 | 0.76 | CYP2D6 (0.54) | PTGS1GAAMAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL6763622 | 0.76 | GAA (0.42) | PTGS1PTGS2GAAMAOBALDH1A1 | |
| SCHEMBL10630231 | 0.75 | PDE4A (0.52) | PTGS1PTGS2GAAPDE4APDE4B | |
| SCHEMBL10633535 | 0.75 | APP (0.51) | PTGS1PTGS2GAAPDE4APDE4B | |
| SCHEMBL6766625 | 0.75 | GAA (0.46) | PTGS1PTGS2GAAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |