Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | UGCG | Q16739 | 3/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763485 | 0.84 | CYP11B1 (0.36) | PTGS1PTGS2GAAPDE4APDE4B | |
| SCHEMBL5781776 | 0.84 | HTR7 (0.38) | PTGS1PTGS2GAAKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL5780676 | 0.83 | HTR7 (0.37) | PTGS1PTGS2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6766907 | 0.83 | PTGS1 (0.50) | PTGS1PTGS2GAAPDE4APDE4B | |
| SCHEMBL5779974 | 0.81 | POLB (0.40) | PTGS1GAAKMT2AALDH1A1KDM4E | |
| SCHEMBL6768461 | 0.81 | TDP1 (0.41) | GAAKMT2AKDM4EMEN1CYP1A2 | |
| SCHEMBL6763407 | 0.80 | TSHR (0.42) | GAAKMT2AKDM4EMEN1CYP1A2 | |
| Hydrochloric Acid SCHEMBL6766915 | 0.80 | TDP1 (0.40) | GAAKMT2AKDM4EMEN1CYP1A2 | |
| Hydrochloric Acid SCHEMBL6766958 | 0.79 | TSHR (0.41) | GAAKMT2AKDM4EMEN1CYP1A2 | |
| SCHEMBL5779879 | 0.79 | POLB (0.45) | KMT2AALDH1A1KDM4EMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-B1 | HETERODIAZINONE DERIVATIVES | EISAI CO LTD (JP) | 2006-04-26 | — | — | EP | claimed |
| EP-1153922-B1 | HETERODIAZINONE DERIVATIVES | EISAI CO LTD (JP) | 2006-04-26 | — | — | EP | disclosed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |