Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.41 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 14/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6768726 | 0.96 | MAP4K4 (0.40) | PRKD3MAP4K4CDK2MAPK1MAPK8 | |
| SCHEMBL6768641 | 0.96 | ACACB (0.39) | PRKD3MAP4K4CDK2MAPK1MAPK8 | |
| SCHEMBL6767746 | 0.92 | MAP4K4 (0.38) | PRKD3MAP4K4CDK2MAPK1MAPK8 | |
| SCHEMBL6768287 | 0.90 | MAPK14 (0.37) | PRKD3MAP4K4CDK2MAPK1MAPK8 | |
| SCHEMBL6763931 | 0.90 | PRKD3 (0.38) | PRKD3MAP4K4CDK2MAPK1MAPK8 | |
| SCHEMBL6766294 | 0.88 | MAPK14 (0.38) | PRKD3MAP4K4CDK2MAPK1MAPK8 | |
| SCHEMBL6763950 | 0.86 | MAPK14 (0.42) | PRKD3MAP4K4MAPK1MAPK9CSNK1A1 | |
| SCHEMBL6769364 | 0.82 | MAPK14 (0.43) | PRKD3MAP4K4MAPK1MAPK9CSNK1A1 | |
| SCHEMBL6766739 | 0.82 | MAPK14 (0.42) | PRKD3MAP4K4MAPK1MAPK9CSNK1A1 | |
| SCHEMBL6768196 | 0.80 | MAPK14 (0.61) | PRKD3MAP4K4CDK2MAPK1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677337-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, INFLAMMATORY BOWEL DISEASE, CACHEXIA, SEPTIC SHOCK, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | THE PROCTER & GAMBLE COMPANY | 2004-01-13 | — | — | US | claimed |
| US-20030225082-A1 | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines | PROCTER & GAMBLE COMPANY, THE | 2003-12-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225082-A1 | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines | IL1B, IL1A, IL1R1 | PRKD3 1836/4885MAP4K4 2666/4885CDK2 1129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.