Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.45 |
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | PTPRZ1 | P23471 | 2/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2097129 | 0.79 | GPR3 (0.46) | CHRM5 | |
| SCHEMBL3033181 | 0.75 | RUNX1 (0.42) | CHRM5 | |
| SCHEMBL6766193 | 0.75 | RXRA (0.47) | SLC6A4ARMRGPRX4RXRARXRB | |
| SCHEMBL12953500 | 0.74 | SLC6A4 (0.51) | SLC6A4ARMRGPRX4RHEBRXRA | |
| SCHEMBL13581057 | 0.74 | TUBB1 (0.51) | SLC6A4ARMRGPRX4MMP1MMP2 | |
| SCHEMBL2096056 | 0.73 | ALOX5 (0.58) | — | |
| SCHEMBL22816423 | 0.73 | SLC6A4 (0.47) | SLC6A4ARMRGPRX4RHEBRXRA | |
| SCHEMBL12953504 | 0.72 | APP (0.59) | SLC6A4ARMRGPRX4RHEBRXRA | |
| SCHEMBL12301144 | 0.72 | RXRA (0.54) | SLC6A4MRGPRX4RHEBRXRARXRB | |
| SCHEMBL30866176 | 0.72 | MRGPRX4 (0.47) | SLC6A4MRGPRX4RHEBRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677379-B2 | SUCH AS 3-((3-(3-TRIFLUOROMETHOXYPHENOXY)PHENYL)((3-(1,1,2,2-TETRAFLUOROETHOXY) -PHENYL)METHYL) AMINO)-1,1,1-TRIFLUORO-2-PROPANOL FOR TREATMENT OF CORONARY ARTERY DISEASE | PHARMACIA CORPORATION | 2004-01-13 | — | — | US | claimed |