Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767123 | 0.86 | MAPT (0.32) | MAPTMAOB | |
| SCHEMBL6770449 | 0.81 | CCNA2 (0.41) | CCNA2CDK2SRC | |
| SCHEMBL6771169 | 0.79 | CCNA2 (0.40) | CCNA2CDK2MAPT | |
| SCHEMBL6766539 | 0.79 | CCNA2 (0.35) | CCNA2CDK2SRC | |
| SCHEMBL6772430 | 0.77 | CCNA2 (0.44) | CCNA2CDK2MAPTSRC | |
| SCHEMBL6770739 | 0.76 | CCNA2 (0.45) | CCNA2CDK2SRC | |
| SCHEMBL6776854 | 0.74 | PTGS1 (0.42) | CCNA2CDK2MAPT | |
| SCHEMBL6767158 | 0.74 | CCNA2 (0.37) | CCNA2CDK2 | |
| SCHEMBL6772549 | 0.74 | CCNA2 (0.35) | CCNA2CDK2MAPTSRC | |
| SCHEMBL6771336 | 0.73 | CCNA2 (0.37) | CCNA2CDK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |