SCHEMBL6776854

SCHEMBL6776854

CC(C)c1ccc(-n2nc(-c3ccco3)c3c2C(C#N)C(C)(C)CC3=O)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.42
CCNA2 P20248 7/20 0.37
CDK2 P24941 7/20 0.37
KDM5A P29375 1/20 0.34
KMT2A Q03164 7/20 0.33
MEN1 O00255 6/20 0.33
HTT P42858 3/20 0.33
LMNA P02545 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
MAPT P10636 6/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
GAA P10253 2/20 0.33
TP53 P04637 1/20 0.33
ALDH1A1 P00352 6/20 0.33
HPGD P15428 5/20 0.33
KDM4E B2RXH2 4/20 0.33
NPSR1 Q6W5P4 4/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6772430 0.86 CCNA2 (0.44) CCNA2CDK2KMT2AMEN1HTT
SCHEMBL6770141 0.86 PTGS1 (0.41) PTGS1KDM5AKMT2AMEN1HTT
SCHEMBL6767158 0.85 CCNA2 (0.37) CCNA2CDK2KMT2AMEN1HTT
SCHEMBL6770739 0.83 CCNA2 (0.45) CCNA2CDK2KMT2AMEN1HTT
SCHEMBL6771336 0.82 CCNA2 (0.37) CCNA2CDK2KMT2AMEN1HTT
SCHEMBL6775773 0.82 CCNA2 (0.39) CCNA2CDK2KMT2AMEN1HTT
SCHEMBL6772794 0.82 CCNA2 (0.40) CCNA2CDK2KMT2AMEN1HTT
SCHEMBL6772549 0.81 CCNA2 (0.35) CCNA2CDK2KMT2AMEN1HTT
SCHEMBL6772109 0.79 CCNA2 (0.37) CCNA2CDK2KMT2AMEN1HTT
SCHEMBL7488247 0.79 OPRM1 (0.49) PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6716856-B1 CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY PHARMACIA & TUBJOHN SPA (IT) 2004-04-06 US disclosed
EP-1177185-A1 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.p.A. (IT) 2002-02-06 EP disclosed
WO-2000069846-A1 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2000-11-23 WO disclosed